A closer look at the downregulated genes contributing to GO terms such as skin development, epidermis development, KC development, and epithelial cell development reveals the downregulation of genes contributing to extracellular matrix formation, intercellular adhesion, and cell arrangement, including Jup, Evpl, Barx2, Arrdc3, and Gja1 (Figure 4c). The gene discussed is JUP; the disease is keratoconus.