Similar to the epidermal changes in Chrm3−/− mice, anti-CHRM3 pemphigus autoantibodies upregulate K5 and downregulate K10 (Chernyavsky et al., 2022) in mice—findings that are mirrored in the epidermis of patients with pemphigus vulgaris (Williamson et al., 2006). Here, CHRM3 is linked to pemphigus vulgaris.