To investigate the correlation of PAQR3 expression and GCA metastasis mediated by the TGF‐β/Smad signaling pathway, we used IHC to examine the expression levels of EMT‐related markers, including E‐cadherins, Vimentin, Snail proteins, and TGF‐β/Smad signaling pathway‐related proteins in GCA tissues, and explored the correlation of PAQR3 with the expression of these proteins. The gene discussed is CDH1; the disease is temporal arteritis.