Knockdown of PAQR3 expression in the colon cancer cell line SW‐480 cells significantly promoted cell proliferation, enhanced EGF (epidermal growth factor)‐stimulated ERK phosphorylation and β‐catenin entering into the nucleus, and knockdown in Apc (APC regulator of WNT signaling pathway)Min/+ mice aggravated intestinal carcinogenesis in mice.17 The gene discussed is EGF; the disease is malignant colon neoplasm.