The levels of PAQR3 protein expression in 146 GCA tissues and their paired PNTs were detected by immunohistochemical (IHC) staining, results showed PAQR3 down‐regulation was detected in 62.3% (91/146) GCA tissues, while PAQR3 in PNTs, 1.4% (2/146) cases were expressed at low levels and 98.6% (144/146) at normal/high levels, the difference between them was significant (p = 0.000) (Figure 1A,B). This evidence concerns the gene PAQR3 and temporal arteritis.