Jiang et al.16found the synergistic function of PAQR3 and p53 in tumorigenesis, also found that they synergistically participate in the EMT process of tumor cells, thus proposed that p53 is a “checkpoint” regulating EMT, and only tumor cells losing the “checkpoint” can effectively perform EMT and then participate in tumor infiltration and metastasis. This evidence concerns the gene PAQR3 and neoplasm.