In particular, one of the major causes of renal hypoxia is acute kidney injury (AKI) in which the hypoxic state is established not only during the acute phase of AKI, but also after the recovery phase as a prolonged hypoxia that results in the downregulation of the proangiogenic isoform 164 and the dysangiogenic isoforms 120 and 188 which upregulate VEGF-A [11]. This evidence concerns the gene VEGFA and acute kidney injury.