To further explore the role of ARHGEF37 in HCC pulmonary metastasis, both Hep3B and Huh7 HCC cancer cell lines stably overexpressing ARHGEF37, or Huh7 and MHCC97H HCC cancer cell lines stably expressing ARHGEF37 shRNAs were established depending on the basic expression of ARHGEF37, respectively (Fig. S2a-S2c). This evidence concerns the gene ARHGEF37 and hepatocellular carcinoma.