ARHGEF37 and hepatocellular carcinoma: To further verify the hypothesis that ARHGEF37 promotes HCC cell adherence to the lung alveoli, monolayer dynamic adhesion assay by seeding GFP+-HCC cells on a monolayer lung microvascular endothelial cell (HMVEC-L) followed by co-culture for 4 h with shaking (Fig. 3c) was performed.