Moreover, silencing Cdc42 significantly abrogated the promotive effect of ARHGEF37 on adhesion and transmigration capabilities of HCC cells (Fig. 5d), suggested that the effect of ARHGEF37 on N-cadherin and Cx43-mediated pericyte–EC interaction was impaired under conditions of Cdc42 silencing. The gene discussed is ARHGEF37; the disease is hepatocellular carcinoma.