WNK1 encodes a serine/threonine kinase that plays an important role in the regulation of electrolyte homeostasis, cell signalling, survival and proliferation, and specific missense variants can cause pseudohypoaldosteronism type IIC (PHA2, also known as Gordon’s syndrome), characterised by hypertension and hyperkalaemia, though with normal renal function, and metabolic acidosis [45, 46]. This evidence concerns the gene MARK2 and pseudohypoaldosteronism type 2.