If the process of macrophages regulating FAPs and Treg cells regulating macrophages cannot be carried out normally, FAPs will eventually promote the production of fibrosis by secreting type I and III collagen and connective tissue growth factor (CTGF) [110], which can be observed in the experiment of mdx mice, and may be the pathological basis of muscular dystrophy [15, 44]. The gene discussed is CCN2; the disease is muscular dystrophy.