Arguably, the most prominent examples are provided by the successes with anti-programmed cell death 1 (PD-1) in CRC contributed by the selection of microsatellite instability high (MSI-H) [7], which were granted approval by the U.S. Food and Drug Administration (FDA) for MSI-H mCRC patients in May 2017 [8]. The gene discussed is PDCD1; the disease is colorectal carcinoma.