Increased density of TILs, a prominent inflammatory reaction, and activated HIF-1α may explain that significantly higher MTV (33.60) and TLG (229.03), reflecting the number of cells with abnormal metabolism, of primary MSI-H CRC than MSS ones (18.08, and 134.26, respectively; P = 0.004 and 0.010, respectively) in present study. The gene discussed is HIF1A; the disease is colorectal carcinoma.