Importantly, TRPC3 silencing or an inhibitor of TRPC3 (Pyr3) treatment dramatically reversed increased migration and invasion of ovarian cancer cells and metastasis of xenograft induced by PLAA downregulation, suggesting that TRPC3 is a downstream target of PLAA, participating in PLAA mediating ovarian cancer metastasis. The gene discussed is PLAA; the disease is ovarian cancer.