Interestingly, the latter mechanism has also been observed in patient-derived PDAC xenografts in which VSV-infected CAFs sensitized tumor cells to VSV infection by downregulation of the antiviral retinoic acid-inducible gene I (RIG-I) via production of fibroblast growth factor 2 (FGF2) [13]. The gene discussed is RIGI; the disease is neoplasm.