Overexpression of JAM-A in the JAM-A negative PSC line hPS1 [15] (Fig. 3A), naturally resistant to reovirus-induced cell death, led to strongly increased cell death induced by reovirus infection and already resulted in productive infection, indicated by σ3 expression, at low MOI (Fig. 3B, supplementary figure 5). This evidence concerns the gene HPS1 and Reoviridae infectious disease.