Because NUPR1 inhibition is accompanied of hyperPARylation and this hyperPARylation could be responsible of cell death, we evaluated the effect of the inhibitor of PARP1, olaparib, and of the inhibitor of dePARylation, PDD00017273, on cell death induced by ZZW-115 on four primary pancreatic cancer cells. This evidence concerns the gene PARP1 and familial pancreatic carcinoma.