NEMOSMCiKO/ApoE−/− and ApoE−/− mice showed similar body weight and serum levels of cholesterol and triglycerides after HFD treatment (Fig. 1a–c), indicating that SMC-specific deletion of NEMO did not affect HFD-induced obesity or basic lipid metabolism. Here, IKBKG is linked to obesity due to melanocortin 4 receptor deficiency.