Additionally, both excitatory (PSD95- and VGlut1-positive puncta) and inhibitory (VGAT- and Gephyrin-positive puncta) synapses were detected, though in low numbers, for both control and MJD organoids, which is also an indication of partial neuronal and organoid maturation. The gene discussed is SLC17A7; the disease is Spinocerebellar ataxia type 3.