ARVC is often caused by variants in genes, encoding proteins in the cardiac desmosome, including plakophilin-2 (PKP2), desmoglein-2 (DSG2), desmocollin-2 (DSC2), desmoplakin (DSP) and plakoglobin (JUP). This evidence concerns the gene DSP and arrhythmogenic right ventricular cardiomyopathy.