ARVC is often caused by variants in genes, encoding proteins in the cardiac desmosome, including plakophilin-2 (PKP2), desmoglein-2 (DSG2), desmocollin-2 (DSC2), desmoplakin (DSP) and plakoglobin (JUP). The gene discussed is PKP2; the disease is Arrhythmogenic right ventricular dysplasia.