CCNB1 and ductal breast carcinoma in situ: Of the total 16 proteins that significantly changed from preneoplastic to DCIS, we identified 6 proteins (FoxO3a_ pS318_S321, Bcl-xL, Cyclin-B1, MEK2, 4E-BP1_pS65 and S6_pS235_S236) that showed a pattern of continuous and significant change across the model system through to DCIS, the final targetable step for prevention of invasive disease (Fig. S2B).