As with the small molecule inhibitors, we found the IC50 value for fluvastatin to be the lowest in the preneoplastic cell lines, MCF10.NeoT and MCF10.AT1 (15.27 and 14.10 μM, respectively), compared to the MCF10.DCIS cells (65.49 μM) (Fig. 4A,B and Fig. S8), and this pattern correlated with an increasing basal level of HMGCR in DCIS cells (1.7-fold in MCF10.DCIS cells, p < 0.05 relative to MCF10.NeoT cells) (Fig. 4C,D). Here, HMGCR is linked to ductal breast carcinoma in situ.