Similarly, for the MEK inhibitor PD0325901, after 48 h of drug treatment, the IC50 value for PD0325901 was found to be lowest in the MCF10.NeoT (5.67 nM) cells, followed by 9.80 nM in MCF10.AT1 cells and 16.73 nM in the MCF10.DCIS cells (Fig. 3A,B). The gene discussed is MAP2K7; the disease is ductal breast carcinoma in situ.