HSD11B2 and Hyperglycemia: On the other hand, studies have revealed that exposure to dexamethasone10, as well as administration of carbenoxolone as inhibitor of placental 11 beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2) during pregnancy resulted in hyperglycemia, hyperinsulinemia, and impaired glucose tolerance in 6-months old rat offspring42.