Since Ephrin signalling in PTEN-deficient PCa was associated with adverse outcome, which our in vitro data suggested was mediated by non-canonical activation via pEphA2S897, we sought to evaluate the influence of the upregulation of EphA2 markers on long-term overall survival using a PCa TMA cohort (n = 177) (patient demographics shown in Supplementary Data Table 2). Here, EPHA2 is linked to posterior cortical atrophy.