Significant reduction in disease-free survival was observed amongst PCa patients with upregulated Ephrin signalling and PTEN-deficiency as compared with PCa patients with low Ephrin signalling and PTEN expression (univariate HR 8.43; 95% CI 2.53–28.05; P = 0.001 and HR 9.93; 95% CI 3.82–25.82; P < 0.001 for TCGA-PRAD and MSKCC datasets respectively (Fig. 1b and Supplementary Table 3). Here, PTEN is linked to posterior cortical atrophy.