Although the high expression of either EphA2 or pEphA2S897 adversely impacted overall survival in the whole cohort, these features were most prognostic amongst patients with PTENlow PCa upon univariate Cox regression analysis (EphA2hi: HR 2.96, 95% 1.35–6.50, P = 0.007; pEphA2 S897hi: HR 1.98, 95% CI 1.20–3.29, P = 0.008) (Fig. 3b, c and Table 1). The gene discussed is EPHA2; the disease is posterior cortical atrophy.