Characterisation of the molecular mechanism behind AA-induced amoeboid transformation has shown that non-canonical ligand-independent EphA2 signalling [17] is critical for AA-induced PCa endothelial transmigration [16, 18] and therefore it is of critical importance in the development of metastatic spread, the lethal form of prostate cancer. The gene discussed is EPHA2; the disease is posterior cortical atrophy.