On the other hand, pS6 and CD98 were significantly higher increased in both conventional and IL-7 secreting CD4 + CAR-T cells co-cultured with tumor cells (comparably higher level of upregulation in 28z/IL-7 group) while GOT2, that plays a role in amino acid metabolism, was significantly upregulated in IL-7 secreting CD4 + CAR-T cells. Here, IL7 is linked to neoplasm.