GPNMB and psoriasis: In addition, gene sets known to be affected in psoriasis were highlighted, including cytokines (Il17a, Il17f, Il18, Il20, and Il22), chemokines (Ccl20, Ccl27a, and Ccl27b), AMPs (S100a8 and S100a9), epidermis development (Lce3f, Sprr2b, and Krt15), tissue repair-related genes (Il10ra, Mmp2, Mmp9, Hgf, Igf1, and Tgfb1), and phagocytosis-related genes (Trem2, Gpnmb, Cd5l, and Fcrls) (Fig. 2e and Supplementary Fig. 3c).