The expression of many genes known to be associated with psoriasis, including Lce3f, Sprr2b, Krt15, S100a8, S100a9, Il17a, Il17f, Il18, Il20, Il22, and Ccl20, was downregulated in the skin of IMQ-treated Camk4−/− mice compared with those of IMQ-treated Camk4+/+ mice. This evidence concerns the gene S100A8 and psoriasis.