CAMK4 expression in the cells of peripheral blood from patients with psoriasis was positively correlated with the expression of IL1B and IL12B. IL-1β and IL-12 are mainly secreted by monocytes/macrophages66,67, and CaMK4 inhibition downregulated the expression of IL1B and IL12B in monocytes, indicating that CaMK4 is likely involved in monocyte-derived IL-1β and IL-12 production. The gene discussed is IL1B; the disease is psoriasis.