We found significant enrichment of RAE1, a SE60 cis direct target, and EPHA2, a SE14 cis direct target, within the cancer cell fraction as compared to the normal cell fraction (Wilcoxon Rank Sum tests, Bonferroni-corrected p-values < 2.2e−308 and average logFC ≥ 0.1) (Fig. 7b). Here, EPHA2 is linked to cancer.