AGT and aortic aneurysm: Sclerostin demonstrated a protective role in the cardiovascular system and could inhibit inflammatory cytokines and chemokines to prevent both aortic aneurysm (AA) and atherosclerotic development induced by angiotensin II (AngII) in Apolipoprotein E deficient (ApoE−/−) mice with transgenic introduction of sclerostin or administration of recombinant sclerostin7.