PSEN1 and Alzheimer disease: For example, APP/PS1 mice, which express human transgenes for APP with the Swedish mutation (K670N/M671L) and PS1 with the L166P mutation under the control of the neuronal-specific Thy1 promoter, are a widely used model of accelerated Aβ accumulation, which makes them a suitable model to study effects of long-term HFD consumption on AD pathology [26].