Moreover, we further find that SENP3 expression positively correlates with the expression of immune response genes in p53 mutant pancreatic cancer patients from TCGA database, suggesting that increasing SENP3 expression can be instead of reducing mitotic SENP3 phosphorylation to activate innate immune response even in p53-mutant tumors. The gene discussed is TP53; the disease is familial pancreatic carcinoma.