Quantitative analysis demonstrated that the micronucleus positive cells were up to ~50% among SENP3–9A-U2OS cells as compared to ~20% positive cells among SENP3-WT-U2OS cells, confirming that SENP3–9A expression increases the formation of micronuclei in tumor cells (Fig. 3A). Here, SENP3 is linked to neoplasm.