Interestingly, the Gene Sets Enrichment Assay (GSEA) [41] shows that most of top upregulated gene sets in SENP3 high vs. SENP3 low are related to inflammation and immune response, which are enriched in SENP3 high tumor samples from the pancreatic cancer patients with chemotherapy (Fig. 5B, C). Here, SENP3 is linked to neoplasm.