A study showed that activation of JNK signalling in metastatic breast tumour cells (metastasis-initiating breast tumour cells) obviously promotes activation of fibroblasts by IL-1α/β, which interact with IL-1R on fibroblasts in the lung to stimulate NF-κB-mediated induction of CXCL-9/10 during the process of lung colonization. This evidence concerns the gene IL1R1 and breast neoplasm.