DKK1 and neoplasm: Similarly, Dickkopf 1 (Dkk-1) derived from MSCs -from the human dermis inhibits Wnt/β-catenin signalling in breast cancer cells, leading to a delay in the tumour formation of SCID mice injected with a mixture of tumour cells and MSCs (approximately 20.6 days), while the control group was developed tumours faster (approximately 6.5 days) [54].