Each of these phosphosites are consistent with our SMOC2 induction of RCC migration and pseudopodal extensions because Y397 phosphorylation was shown to be critical for the invasive properties of FAK in oral squamous cell carcinoma cells [58], Y118 phosphorylation on paxillin regulates cell migration in Nara Bladder Tumor II (NBT-II) cells [59], and Y925 phosphorylation of FAK is required for FAK-mediated cell migration and cell protrusion in mouse embryonic fibroblasts [60]. This evidence concerns the gene PTK2 and oral cavity squamous cell carcinoma.