RNA-seq analysis in isolated human islets suggested that PIEZO1 gene expression is significantly (p = 0.023) increased in donors with type-2 diabetes (T2D) and also the donors with impaired glucose tolerance (IGT) (p = 0.015) compared to levels found in normoglycemic donors (Fig. 1b). The gene discussed is PIEZO1; the disease is type 2 diabetes mellitus.