Single-nucleotide polymorphisms in ALPK1 have been associated with an increased risk of gout, while rare variants have been identified in patients with recurrent periodic fevers.9–11 These data suggested that patients with ROSAH may have an inflammatory signature. The gene discussed is ALPK1; the disease is retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome.