ACE2 and Cognitive impairment: A combined reduction of cerebral blood flow by ∼20% is expected to lead to cognitive impairment such as an inability to maintain attention and white matter damage.62–64 How long this reduction of blood flow lasts may depend on the time needed for the surface membrane ACE2 level to recover after SARS-CoV-2 infection, which may in turn depend on whether long-term damage is evoked in pericytes.