AGT and neoplasm: To assess whether the potentiation of capillary constriction, characterized above in hamsters, also occurs in human capillaries, we employed brain slices made from live human brain tissue that was removed in the course of tumour removal surgery.15 Consistent with the similar binding33 of the SARS-CoV-2 RBD to human and hamster ACE2, we found that the RBD greatly potentiated the pericyte-mediated constriction evoked in human capillaries by 50 nM angiotensin II (Fig. 4B and C).