We then subjected naïve B cells from P, and patients with autosomal dominant (AD) partial IFN-γR1 deficiency (79-81), dominant negative (DN) STAT3 deficiency (82), AD or AR STAT1 deficiency (82-84), AR complete IL-27R deficiency (unpublished), partial recessive JAK1 deficiency (unpublished), or AR IRAK4 deficiency (67, 85) to these culture conditions. Here, IFNGR1 is linked to Alzheimer disease.