PTEN and posterior cortical atrophy: As expected, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of genes up-regulated in prostatic luminal cells of Pten(i)pe−/− mice revealed a number of cancer-associated pathways, such as “proteoglycans in cancer,” “PCa,” and “PI3K-Akt signaling” (Fig. 1C).