To identify genes in the luminal-C2 signature that are associated with HIF1A-driven PIN progression, we overlapped the top 100 DEGs in luminal-C2 cells with those identified in the trajectory inference analysis and correlated the expression of the common genes with those of HIF1A in human PCa transcriptomes on The Cancer Genome Atlas (TCGA) database (fig. This evidence concerns the gene HIF1A and posterior cortical atrophy.