As PIN evolution was impaired by Hif1a inactivation, we compared the expression of SOX2 (SRY-box transcription factor 2) and EZH2 (Enhancer of zeste homolog 2), two known regulators of PCa progression and plasticity (27, 28), in prostates of Pten(i)pe−/− and Pten/Hif1a(i)pe−/− mice. This evidence concerns the gene HIF1A and posterior cortical atrophy.