In addition, in human PCa transcriptomes of the TCGA PRAD (Prostate Adenocarcinoma) cohort, TGM2 levels positively correlated with an HIF1A signature consisting of 10 known HIF1A targets (SLC2A1, HK2, PFKA, ALDOA, GAPDH, ENO1, LDHA, CA9, BNIP3, and VEGFA), a human PCa-specific hypoxia signature (32), and a general hypoxia signature obtained from the molecular signatures database (33) (fig. Here, PFKM is linked to posterior cortical atrophy.