Combinations of ratios kC1,growth/kC,T1, kT1/kTreg, and the parameter Treg,max, where kC1,growth, kC,T1, kT1, kTreg, and Treg,max are the cancer cell growth rate, the rate of cancer cell death by T cells, the exhaustion rate of cytotoxic T cells by all cells that express PD-L1, the inhibition rate of cytotoxic T cells by regulatory T cells, and the maximal regulatory T cell density in the tumor, respectively. The gene discussed is CD274; the disease is neoplasm.