Interestingly however, this did not impact overall survival or PDAC-free survival in this model (Fig. 1 A and B, and SI Appendix, Tables 1 and 2); suggesting that the biggest contributing factor to death due to loss of Atg7 in this model is not PDAC, but diabetes and pancreatic insufficiency. Here, ATG7 is linked to exocrine pancreatic insufficiency.