TP53 and Li-Fraumeni syndrome: In contrast to the TP53 gene, the mutations of which are linked to the Li-Fraumeni syndrome [26], TP73 has not been associated with any hereditary disease so far, likely due to its involvement in many developmental and homeostatic processes, e.g., regulation of neural stem cell survival, self-renewal and differentiation in neurogenesis, regulation of multiciliogenesis, male and female reproduction, angiogenesis and immune response.