Hierarchical clustering of DEGs of the innate immune response demonstrated that ASFV-Δ9L/Δ7R infection resulted in higher transcriptional induction of the interferon response, especially IFN-induced genes, such as IFN-induced proteins with tetratricopeptide repeats (IFITs), RIG-I-like receptors (RLRs), namely, MDA5 (IFIH1), RIG-I (DDX58), and LGP2 (DHX58), IFN-inducible guanylate binding proteins (GBP), and IFN-stimulated ubiquitin-like proteins (ISG15). The gene discussed is ISG15; the disease is infection.