Heterogeneous nuclear ribonucleoprotein D (HNRNPD), epsin 2 (EPN2), and tripeptidyl peptidase 1 (TPP1), among others, showed reduced protein levels when cotransfected with CTSW compared to their levels in the green fluorescent protein (GFP) control, regardless of infection (Fig. 2E and Fig. S1). The gene discussed is EPN2; the disease is infection.