We postulated that our low-proliferative miR-181 KO liver tumours may resemble the ppHCC subtype, as miR-181ab1 KO tumours showed increased expression of some genes, such as CBX7 and FOXP2, which were mainly expressed in periportal hepatocytes (periportal genes) (Supplemental data, Fig. S6A-B; Fig. 5D, E). The gene discussed is CBX7; the disease is neoplasm.