Expression levels of seven CBX7 targets, namely Wnt10a, Ccne1, Fgfr2, Bhlhe22, Klhdc8a, Pde10a, and Dusp4, which had been significantly inhibited in miR-181ab1 KO compared to WT tumours in mice (Fig. 5H), were also significantly lower in either iClust2 or iClust3 than iClust1 HCCs (Fig. 8A). The gene discussed is DUSP4; the disease is neoplasm.