Based on hypoglycaemic glucose clamp studies dating back to the 1980s, it is commonly assumed that the physiological response to hypoglycaemia in healthy people occurs at glucose levels below 3.9 mmol/l, with the release of glucagon and adrenaline, whereas glucose levels below 3.3–3.5 mmol/l are reported to trigger symptomatic awareness [72]. This evidence concerns the gene GCG and Hypoglycemia.