Membrane type-1matrix metalloproteinase (MT1-MMP, also known asMMP-14) is a cell surface enzyme overexpressed in a range of cancers,including sarcoma, and is associated with tumor growth, invasion,metastasis, and angiogenesis.14 MT1-MMPbelongs to a family of MMPs that degrade components of the extracellularmatrix (ECM).15 The principal role of MT1-MMPinvolves degradation and remodeling of collagen and proteoglycans;however, it also activates other proteolytic MMPs, which themselvesdegrade ECM components, leading to increased invasion of the basementmembrane. The gene discussed is MMP14; the disease is sarcoma.