The univariate analysis showed that there were significant differences in age, current smoking status, length of hospital stay, cough, shortness of breath, nausea or vomiting, chest distress, inappetence, comorbidities such as hypertension, diabetes, cerebrovascular disease, and cancer, SaO2 <95%, white blood cell count >10.0 × 109/L, lymphocyte count <0.8 × 109/L, CRP level ≥10 mg/L, LDH level ≥250 U/L, AST level >40 U/L, ESR, sodium level, and CD4+ T cells counts between the two groups (P < .05, Table 1). This evidence concerns the gene ESR1 and cerebrovascular disorder.