IL6 and Insulin resistance: Regarding folliculogenesis, cytokines regulate cell proliferation or differentiation, follicle survival or atresia, and oocyte maturation.[8] IL-6 levels in the follicular fluid are significantly higher than those in the serum.[9,10] In the polycystic ovary syndrome, IL-6 levels increase in the serum as well as in the follicular fluid due to an increased secretion by the granulosa cells, and some studies have shown that increased IL-6 levels may be associated with hyperandrogenism and insulin resistance.[11]