ALECT2 was recently considered as a new clinicopathologic type of amyloid, which frequently affected kidney in adults and resulted in different degree of renal insufficiency and failure with or without proteinuria.[7] The process appeared to be confined to the kidney; however, previous studies have discovered that extensive LECT2 deposition in the liver, heart, spleen, adrenal glands, colon, small intestine, gallbladder, lungs, bilateral ovaries, and uterus.[8–10] There is current paucity of studies describing the etiology, pathogenesis, or prognosis of ALECT2. The gene discussed is LECT2; the disease is Renal insufficiency.