AIM2, as a representative of the NOD-like receptor family inflammasomes,[16–18] activates a network of caspases including caspase-1 and caspase-8 and promotes both pyroptotic and apoptotic cell death.[19] Kong et al[20] documented that the AIM2 inflammasome was overexpressed in non–small cell lung cancer. Here, CASP8 is linked to lung cancer.