LMNA and Hutchinson-Gilford progeria syndrome: In ~90% of cases, HGPS is caused by a de novo point mutation C > T in position 1824 of the LMNA gene, within the exon 11, which creates an alternative 5ʹss and results in the production of progerin, a partially deleted form of nuclear lamin A responsible for dysfunctional nuclear membrane and premature senescence [125].