The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma Gut Gut 2005 2005 54 54 1283 1283 1286 1286 10.1136/gut.2005.066514 10.1136/gut.2005.066514 15843421 15843421. This evidence concerns the gene KRAS and colorectal carcinoma.