49 de Vogel de Vogel S S Weijenberg Weijenberg MP MP Herman Herman JG JG Wouters Wouters KA KA de Goeij de Goeij AF AF van den Brandt van den Brandt PA PA MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: Indications for distinct pathways and sequence of events MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: Indications for distinct pathways and sequence of events Ann Oncol Ann Oncol 2009 2009 20 20 1216 1216 1222 1222 10.1093/annonc/mdn782 10.1093/annonc/mdn782 19164452 19164452. The gene discussed is APC; the disease is colorectal cancer.