CRP and obesity due to melanocortin 4 receptor deficiency: As expected, in our study, periodontitis patients demonstrated higher CRP levels than did the non-periodontitis group.3,32,67,80 CRP, a marker of systemic inflammation, can also arise from obesity-driven low-grade systemic inflammation.19,57 However, previous research showed that periodontitis could increase CRP levels in obese patients by about 1 mg/l,40 whereas successful periodontal therapy could reduce CRP levels by about 1 mg/l CRP.5,70,80 On the other hand, higher GGT levels in the gingivitis group may reflect severe hepatocyte damage.