ANXA6 and familial dilated cardiomyopathy: In a study of human idiopathic dilated cardiomyopathy (DCM), left ventricle samples showed a 1.2-fold increase in annexin A6 protein expression in failing hearts (n = 11) compared with nonfailing hearts (n = 9), with annexin A6 localization at the sarcolemma and transverse tubules (66).