The conclusion in relation to preeclampsia is consistent with a previous study that measured total and free PlGF in the serum of women with preeclampsia.23 These authors observed that among women with preeclampsia, there was no difference in total PlGF, but there were reduced levels of free PlGF, indicating that reduced levels detected by ELISA reflected increased binding by sFLT1. This evidence concerns the gene PGF and preeclampsia.