FLT1 and preeclampsia: Recently, a randomized controlled trial demonstrated that knowing PlGF levels reduced the time for clinical confirmation of the disease in women with suspected preeclampsia and improved maternal outcome.32 FLT1 and PlGF concentrations at 35 to 37 wkGA in the highest and lowest 5th centile, respectively, were associated with FGR,33 and abnormal maternal levels of these factors and of the sFLT1:PlGF ratio have been measured at various gestational ages in pregnancies with small infants, defined using multiple definitions of reduced fetal growth.5,34