Activating TFRC increases the iron content, mediates the release of ROS, and induces lipid peroxidation, which further promotes the ferroptosis of cells [37]; however, knocking down TFRC significantly inhibits cancer cell proliferation and metastasis via up-regulation of AXIN2 expression or sponge of microRNA-107 [38,39]. This evidence concerns the gene AXIN2 and cancer.