CRH and alcohol abuse: CRF is a neuropeptide encoded from the crh gene that is highly involved in stress and fear response and is heavily implicated in alcohol use disorder (Koob, 2010; Silberman and Winder, 2015; Silberman et al., 2015; Varodayan et al., 2017a; Agoglia and Herman, 2018; de Guglielmo et al., 2019).