Specifically, SST+ and PKCδ+ neurons are mutually inhibiting, and activation of SST neurons leads to inhibition of PKCδ neurons projecting to the CeAM, resulting in a disinhibition of the CeAM outputs to promote anxiety-like behaviors (Haubensak et al., 2010; Li et al., 2013; Penzo et al., 2014). The gene discussed is SST; the disease is Anxiety.