ABCB11 and cholestasis: Substances binding to hERG can lead to severe torsades des pointes27 and BSEP blockers often lead to cholestasis.28 Alongside (off)‐targets, (toxico)kinetics, especially in junction with genetic components, also plays an important role in the elucidation of toxicity mechanisms.29 Using kinetics, the exposure defines whether a hazard becomes an imminent risk.