Moreover, vitamin D can reverse cognitive impairments by the elevation of hippocampal BDNF concentrations in high-fat diet-induced obese Wistar rats (orally with 500 IU/kg vitamin D for 5 weeks) (63) and protect against hippocampal apoptosis in seizure Sprague Dawley rats model (orally with 500 IU/kg for 2 weeks) (64). Here, BDNF is linked to Cognitive impairment.