For example, the administration of vitamin E (α-tocopherol at a dose of 100 mg/kg once daily via oral gavage for 6 weeks) has been shown to prevent high-fat high-carbohydrate diet-induced memory impairment, with normalized SOD activity, thiobarbituric acid reactive substances levels, and oxidized glutathione in the hippocampus of adult male Wistar rats (50). Here, SOD1 is linked to memory impairment.